The present pandemic revived the memory of a long history full of endemics, epidemics, and pandemics that spread among all nations and devastated them. The people passed by difficult times like what we are passing through nowadays with the spread of the COVID-19 pandemic. The history is repeating itself: people at those times had no clue of what hit them, what is the source of the disease? How to treat the patients? or How to stop the infection wave at its track? In this book I presented the most known infectious diseases that threatened human life in the past to the present. In addition, I included some of historical anecdotes that will make reading the book less intense.The author Dr. Ayman Elhossiny is a prolific writer in the medical and public health information field, with a long list of publications that were published and distributed by several publishers around the world: both in English and Arabic. Dr. Elhossiny is specialized in Internal Medicine and practices medicine in his private clinic. He has expertise in alternative medicine as well. The present spread of the coronavirus has motivated him to provide medical information on infectious diseases. Furthermore, he authored and coauthored published books covering the cultural, medical, and political aspects of the COVID-19 pandemic.