Epigenetics and Disease

Name: Epigenetics and Disease
SKU: 8392367
Price: 522.99 AUD
Availability: InStock

Pharmaceutical Opportunities

Format:

Hardback

Series:

Progress in drug research

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Description

Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.

Release date Australia

October 2nd, 2010

Audience

Professional & Vocational

Contributors

Edited by En Li
Edited by Susan M Gasser

Illustrations

X, 270 p.

Pages

270

Series

Progress in drug research

Dimensions

155x235x20

ISBN-13

9783764389888

Product ID

8392367

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