Online learning has been touted as one way of reducing the cost of higher education while simultaneously addressing the increasing demand for educational opportunity and providing access to hitherto “left out” populations. Many universities are defying tradition by offering completely online degrees for global participants. As such, research is needed to improve the design of online and virtual learning environments to ensure that they are inclusive and culturally adaptive for the global education marketplace. The Handbook of Research on Cross-Cultural Online Learning in Higher Education shares paradigms, perspectives, insights, challenges, and best practices for the instructional design and delivery of cross-cultural adult web-based learning experiences and examines adult learner characteristics and competencies critical for the design of these applications. The content within this publication covers trending topics including virtual learning, culturally adaptive environments, and online education and is intended for instructional designers, faculty, administrators, students, and researchers.