This Handbook offers a comprehensive guide to sustainable practices in nature-based tourism (NBT), focusing on the critical need to combat climate-related challenges. Multidisciplinary in scope, it highlights innovative governance models, community engagement, and transdisciplinary collaboration for sustainable NBT management, as well as adaptive strategies for NBT to thrive in changing climates. Bringing together an array of experts from the Global South and North, the Handbook underscores the importance of integrating climate considerations into tourism strategies for resilience and sustainability. Contributing authors provide actionable information and strategies for destination managers, focusing on reducing emissions, fostering ecosystem regeneration, and ensuring financial sustainability. The book is a key resource for navigating climate challenges in tourism and advocates for informed, strategic actions going forward. With its wealth of international case studies and focus on practical strategies for managing nature-based tourism destinations, this book is an essential read for students and researchers in tourism studies, as well as tourism practitioners and policymakers interested in the sustainable development of tourism.