This volume evaluates the findings of nearly 600 studies aimed at determining whether the health risks associated with tobacco use are enhanced by co-exposure to numerous chemical, biological and physical agents commonly found in the workplace. Co-exposures in the domestic and general environment, which are especially important in newly-industrializing countries, are also considered in this review. Although all forms of tobacco use are covered, particular attention is given to risks arising from exposure to mainstream and sidestream smoke from cigarettes. The book has four chapters. The first summarizes what is known about the health risks caused by tobacco use. The second, and most extensive, evaluates the evidence on health effects caused by interactions between tobacco smoke and asbestos, non-asbestos fibres, seven inorganic chemicals, five organic chemical agents, including ethanol, four physical agents, and seven biological agents, including two wide-spread infectious agents. Chapter Three considers whether adverse effects following co-exposure to tobacco smoke and other agents are separate effects or possible interactions. On the basis of the report's findings, the final chapter concludes that all possible measures should be taken to eliminate tobacco use, particularly smoking. It suggests that smoking in the workplace should be prohibited, and that, since smoking can result in altered responses or adverse reactions to drugs and other treatments, appropriate dose adjustments and patient surveillance should be taken into consideration by clinicians.