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Heteroaromatic Lipoxin A4 Analogues on Hardback by Colm Duffy
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Heteroaromatic Lipoxin A4 Analogues

Synthesis and Biological Evaluation
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Description

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work inĀ  the synthesis of further heteroaromatic analogues for biological evaluation.
Release date Australia
January 5th, 2012
Author
Audience
  • Professional & Vocational
Illustrations
XXII, 130 p.
Pages
130
Dimensions
155x235x15
ISBN-13
9783642246319
Product ID
18500186

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Heteroaromatic Lipoxin A4 Analogues by Colm Duffy
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