Hydrothermal Nanocomposites for Tissue Engineering Hydrothermal nanocomposites have emerged as a promising approach in the field of tissue engineering, offering unique properties and capabilities for regenerative medicine applications. Through the integration of hydrothermal synthesis and the incorporation of nanoscale metal oxide particles, these nanocomposites provide an innovative solution to address the challenges associated with tissue regeneration. Hydrothermal growth involves a controlled synthesis process that occurs in a high-pressure, high-temperature aqueous environment. This method allows for the precise formation and growth of nanoscale particles, including hydroxyapatite and metal oxides, which are critical components for tissue engineering applications. Hydroxyapatite, a bioactive ceramic, provides structural support and mimics the mineral composition of natural bone, making it an ideal candidate for promoting bone tissue regeneration. The inclusion of metal oxide nanoparticles offers additional benefits, such as improved mechanical properties, enhanced biocompatibility, and controlled drug delivery capabilities. The unique combination of hydrothermal growth and nanocomposite design allows for the tailoring of material properties to meet specific tissue engineering requirements. The nanoscale nature of these composites facilitates cellular interactions, promoting cell adhesion, proliferation, and differentiation. Furthermore, the incorporation of metal oxides enables the introduction of functional properties, such as antimicrobial activity or controlled release of bioactive molecules, which can enhance tissue regeneration processes. Hydrothermal nanocomposites find application in various tissue engineering areas, including bone, cartilage, and dental tissue regeneration. They can be fabricated into scaffolds, coatings, or injectable materials, providing support and cues for cell growth and tissue formation. Additionally, their versatility allows for the incorporation of other bioactive substances or growth factors, further enhancing their regenerative potential. In summary, hydrothermal nanocomposites represent a promising avenue in tissue engineering, combining the advantages of hydrothermal synthesis and nanotechnology. With their tunable properties, biocompatibility, and potential for multifunctionality, these materials hold great promise for promoting tissue regeneration and advancing the field of regenerative medicine