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Impact of Survivin Acetylation on its Biological Function by David Dannheisig
Impact of Survivin Acetylation on its Biological Function by David Dannheisig
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Impact of Survivin Acetylation on its Biological Function

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Description

In his research, David Dannheisig investigates the influence of lysine129 acetylation on the biological function of survivin including alteration of nucleocytoplasmic shuttling as well as dimerization behavior. Since survivin participates in two major hallmarks of oncogenesis, namely cell death inhibition and chromosomal segregation during the cell cycle, it reflects a valuable target in cancer therapy and research. The author establishes proximity-dependent, fluorescence-microscopic methods to quantify the interaction of survivin with the export receptor Crm1 as well as the homodimerization itself. In the future, those systems can be usedto examine the feasible effect of chemical modulators which are targeting these interactions in a cellular background. The outcome achieved is an essential step towards the enhancement of potential cancer therapies.

Author Biography:

David Dannheisig currently is a student of the International Graduate School in Molecular Medicine (IGradU) pursuing his PhD (Dr. rer. nat) degree at the Institute of Biochemistry and Molecular Biology (iBMB) at Ulm University, Germany.
Release date Australia
June 16th, 2017
Audience
  • Professional & Vocational
Edition
1st ed. 2017
Illustrations
10 Illustrations, color; 31 Illustrations, black and white; XXIII, 104 p. 41 illus., 10 illus. in color.
Pages
104
ISBN-13
9783658186227
Product ID
26835375

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