This essential handbook provides clinicians with the tools to introduce Integrative Systemic Therapy (IST) into their practice working with individuals, couples, and families. Describing the "how to" and "how to decide what to do" aspects of IST, this book outlines a practical, problem-solving approach that considers client strengths and and cultural contexts in the process of integrating interventions from various therapy models and empirically supported treatments. Chapters demonstrate how problem-solving tasks can be accomplished using the IST blueprint for therapy and include scenarios that will challenge the reader to think through the specific steps for IST, encouraging them to consider the therapeutic alliance and the use of self in therapy. For supervisors, trainers, and clinicians familiar with IST, this book will enrich and deepen their understanding of it. The book is also relevant for clinicians and supervisors of all types of therapy who seek to become more integrative and systemic in their work.