The pathogenic microbes, with their determination to survive are gaining resistance by curious mechanisms and most of the effective antibiotics are becoming resistance due to in-discriminant use. As a result, microbial drug resistance is one of the most serious problems which the human-race is facing today. Beside this, new diseases like cancer and newer disease like AIDS are all around the world. So, medical scientists and researchers are searching for newer, safer and more effective and improved antibiotics to combat against drug resistance mutants as well as to combat newer diseases. The present work is a part of such an effort. Aim of the present study was isolation of marine actinomycetes as marine environments are largely untapped source for the isolation of new microorganisms with potentiality to produce active secondary metabolites.