This volume explores the local specificities and global forces that shaped Jewish experiences in the Americas across five centuries. Featuring a range of case studies by scholars from the United States, Brazil, Europe, and Israel, it explores the culturally, religiously, and politically diverse lives of Jewish minorities in the Western Hemisphere. The chapters are organized chronologically and trace four global forces: the western expansion of early modern European empires, Jewish networks across and beyond empires, migration, and Jewish activism and participation in international ideological movements. The volume weaves together into one narrative the histories of communities and individuals separated by time and space, such as the descendants of Portuguese converts, Moroccan immigrants to Brazil, and U.S.-based Yiddish movie makers. Through its transnational focus and close attention paid to local circumstances, this volume offers new insights into the multicultural pasts of the Americas’ Jewish populations and of the different regions that make up North, Central, and South America.