This manual contains chemistry laboratory experiments that are adaptable for use by tribal colleges and community colleges. It was created for a two-semester General, Organic, and Biochemistry course sequence at Nebraska's two tribal colleges over a period of four years. While the authors see chemistry everywhere, we developed these connections to tribal community topics to help students to see the chemistry of everyday life and to find intellectual satisfaction and enjoyment while doing so. The labs can be performed by students alone or in pairs and will require about 2.5 hours to complete if the reagents and materials are ready. All labs have background information, community connections, the lab protocols and procedures, and suggestions for the lab report.