Sometimes it's deadly at the top... Devon O'Keefe, star of the popular streaming TV series Beverly Hills Banshee, is losing her grip on life and her sudden fame. When substance abuse and erratic behavior cause production of her show to come to a halt-and after burning through all of her money on drugs and legal fees-the young Midwestern transplant finds herself alone and homeless in L.A. Enter Nikki Barnes, notorious aging child star and Hollywood survivor with her own tabloid exploits, who waylays Devon after a twelve-step program meeting. Nikki sees a younger version of herself in Devon, having battled addiction, eating disorders, and the effects of personal tragedy for decades. She offers to share her decaying Laurel Canyon mansion with the troubled young actress, determined to help her avoid making the same mistakes she's made. But soon a series of mysterious and disturbing incidents occur and the two women find themselves locked in a complex and twisted relationship that spirals downward into violence. Ladies of the Canyon explores the universal need for family and acceptance, and how a toxic environment can affect the choices we make.