This book represents identification and targeting critical disease signaling pathways in male breast cancer (MBC) towards development of phytochemical-based personalized medicine. The book contains 12 sections where first 3 sections deal with details such as MBC-epidemiology, risk factors, screening and diagnosis, treatment options etc. From sections 4 to 10, rationale of the work and identification of MBC disease signaling pathways, drug targets, targeting phyto-chemicals, and personalized treatment strategies have been described and the results have been concluded in section 11. Section 12 has listed all relevant references used in this work. This is the first of its kind of work towards development of personalized phytochemical-based treatment strategy for MBC. It is a part of D. Barh's PhD work and authors hope that, the strategy will be useful in developing personalized chemo-prevention and phyto-therapy in MBC and will minimize the side effects that are prevalent while using breast cancer specific chemotherapy.