Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors

Name: Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors
SKU: 21758767
Price: 272.99 AUD
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Paperback / softback

Series:

Advances in Experimental Medicine and Biology

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Description

This volume addresses a fundamental puzzle in biology and medicine, namely, how does tissue develop, repair and replace itself. The answer appears to lie in growth factors and their regulation. To thrive and survive we need growth factors and this book concentrates on two factors that are related to growth hormone. Growth hormone does not act directly on all tissues, but mediates many of its actions through the release of insulin-like growth factors from the liver. The growth factors were originally called somatomedins by McConaghey and Sledge (1), who discovered that they mediated growth-like effects of growth hormone. However, the factors were purified on the basis of their insulinomimetic actions on fat and muscle and it is their relationship to the insulin family of pep tides that now gives them their name (2,3) of insulin-like growth factors (IGFs). They mediate the actions of. growth hormone on the proteoglycan synthesis of cartilage and produce mitogenic effects in fibroblast cultures.

Release date Australia

March 19th, 2012

Audience

Professional & Vocational

Contributors

Edited by Derek LeRoith
Edited by Mohan K. Raizada

Edition

Softcover reprint of the original 1st ed. 1991

Illustrations

498 p.

Pages

498

Series

Advances in Experimental Medicine and Biology

Dimensions

178x254x27

ISBN-13

9781468459517

Product ID

21758767

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Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors

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