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Optimization in Drug Discovery on Hardback
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Optimization in Drug Discovery

In Vitro Methods
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Description

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve “drug-like” characteristics in addition to efficacy properties and good safety profiles of drug candidates. Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.
Release date Australia
November 9th, 2013
Audience
  • Professional & Vocational
Contributors
  • Edited by Gary W. Caldwell
  • Edited by Zhengyin Yan
Edition
2nd ed. 2014
Illustrations
49 Illustrations, color; 64 Illustrations, black and white; XVII, 597 p. 113 illus., 49 illus. in color.
Pages
597
Dimensions
178x254x38
ISBN-13
9781627037419
Product ID
21597717

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