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Parkinson's disease is no longer considered only a motor disorder. It has become evident that the pathological changes are broad, the progression seems to follow a pattern suggesting transynaptic transmission via templation of proteins in a prion-like fashion, and that these pathological changes usually antedate the motor symptoms by decades. This book emphasizes treatment options for Parkinson's disease, critically assessing pharmacologic and surgical interventions for all aspects of the disease. Evidence from randomized controlled clinical trials is highlighted to develop practical recommendations for clinical practice. Lessons learnt from clinical trials - and controversies and future challenges - are all addressed. Readers will find the necessary clinical and scientific foundations for the understanding of the disease, the underpinnings of the pathological processes, the identification of disease biomarkers, and the basis for solid therapeutics. Chapters are authored by an international team of specialists who bring their expertise to improving the management of this disease.
Nestor Galvez-Jimenez MD is Professor of Medicine (Neurology-Florida) at Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, and Pauline M. Braathen Endowed Chair, Director of the Neurological Center, Chief of the Movement Disorders Unit, and Chairman of the Department of Neurology, at Cleveland Clinic Florida, Weston, FL, USA. Hubert H. Fernandez is Head of the Division of Movement Disorders at the Department of Neurology, Cleveland Clinic, Cleveland, OH, USA. Alberto J. Espay is Associate Professor of Neurology, Director, and Endowed Chair at the James J. and Joan A. Gardner Center for Parkinson's Disease and Movement Disorders, University of Cincinnati Academic Health Center, Cincinnati, OH, USA. Susan H. Fox is Associate Professor of Neurology at the University of Toronto, Associate Director of the Movement Disorders Clinic at Toronto Western Hospital, and Staff Neurologist in the Division of Neurology, Department of Medicine, University Health Network, Toronto, Canada.
Release date Australia
March 24th, 2016
Edited by Alberto J. Espay
Edited by Hubert H. Fernandez
Edited by Nestor Galvez-Jimenez
Edited by Susan H Fox
Country of Publication
26 b/w illus. 9 colour illus. 48 tables
Cambridge University Press
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