An expert exploration of the foundations of America’s science and technology policies, and the dynamics of its innovation system. Why study science and technology policy? What role does innovation play, and how do we foster it? Economics tells us technological innovation drives economic growth and societal well-being, but technology is always a double-edge sword—great technological advances offer both opportunities and threats. In Pioneering Progress, William Bonvillian explains the complex science and technology innovation system and discusses the challenges of emerging industrial policies. Drawing on in-depth case studies on critical areas such as energy, computing, advanced manufacturing, and health, with an emphasis on the needed public policy and the federal government R&D role in those systems, Bonvillian reviews the foundations of economic growth theory, innovation systems theory, and innovation organization theory. Bonvillian, a highly respected expert who has worked as a Deputy Assistant Secretary of Transportation in the federal government and a senior advisor in Congress, reviews a new theory of direct and indirect economic factors in the innovation system. He describes the innovation-based competitive and advanced manufacturing challenges now facing the U.S. economy, reviews comparative efforts in other nations, studies the varied models for how federal science and technology mission agencies are organized, and explores the growth of public-private partnership and industrial policy models as a way for science mission agencies to pursue mission agendas. Pioneering Progress places particular emphasis on the organization and role of medical science and energy innovation agencies, and how we can address the gaps in the health, energy, and advanced production innovation economic models.