In this issue of Clinics in Liver Disease, guest editor Dr. Pierre M. Gholam brings his considerable expertise to the topic of Portal Hypertension and Its Complications. Portal hypertension is often one of the major complications seen in advanced liver disease. Patients can be asymptomatic for years and considered compensated. How to manage patients prior to the point of hepatic decompensation is of utmost importance, due to the impact on life expectancy and quality. The timely clinical reviews in this issue will help hepatologists manage these patients and improve outcomes. Contains 12 relevant, practice-oriented topics including non-invasive assessment of portal hypertension; radiological and surgical treatments of portal hypertension; bleeding complications of portal hypertension; cognitive issues and portal hypertension; surgical considerations in portal hypertension; and more. Provides in-depth clinical reviews on portal hypertension and its complications, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.