In the city of Townsville, the frustrated Professor Utonium is gathering all the ingredients to make a perfect little girl (sugar, spice, and everything nice). But when his lab assistant, a monkey named Jojo, causes the accidental addition of Chemical X to the mix, the Professor ends up with not one but 3 perfect, powerful little girls. It soon becomes obvious that Blossom, Bubbles, and Buttercup are not normal girls, they have superpowers and have not yet learned to control.