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Protein Expression in Down Syndrome Brain on Hardback
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Protein Expression in Down Syndrome Brain

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Description

This book presents latest original research work and current opinions on Down syndrome, focussing on the molecular biology of the Down syndrome brain at the protein level, rather than at nucleic acid level, as it is the proteins that do the work, and there is a long and unpredictable way from RNA to protein. The studies used fetal brains with Down syndrome in which no neurodegeneration was found and characterized proteins by two-dimensional gel electrophoresis and mass spectrometry. The book provides new aspects, such as that neuronal density and neurotransmission is unchanged in early life but synaptosomal structures and dendritic spines are already seriously affected at the early second trimester. The presentation of a series of tentative mechanisms for the development of the Down syndrome neurophenotype provides models for present and future thinking on the neurobiology of the Down syndrome brain.
Release date Australia
October 15th, 2001
Audience
  • Professional & Vocational
Contributor
  • Edited by G. Lubec
Illustrations
X, 374 p.
Pages
374
Dimensions
210x279x22
ISBN-13
9783211837320
Product ID
5267927

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