The stage to Yuma was down and the Jicarilla Apaches were attacking. The driver had been killed and only Tom Quinn now stood between the renegades and the young blonde woman travelling with him. The arrival of Sheriff Mike Hancock appears to ease the crisis but, in fact, complicates matters even further. Hancock is escorting a murderer to Yuma Prison and now Quinn must take him aboard the coach as well. Pressed into service, Quinn must drive the stagecoach across a hundred miles of dangerous country, rife with Indians, infested by border raiders and complicated by the arrival of the one particular passenger. This is no way to begin a career as a stage driver, and the question hovers ominously - is this to be Quinn's first run or his last?