This volume contains the proceedings of the 2010 Runtime Veri?cation conf- ence (RV 2010), which was held in St. Julians, Malta on November 1-4, 2010. The conference program included a mix of invited talks and peer reviewed p- sentations, tutorials, and tool demonstrations. The 2010 Runtime Veri?cation conference was a forum for researchers and industrial practitioners to present theories and tools for monitoring and anal- ing system(softwareandhardware)executions,aswell asa forumfor presenting applications of such tools to practical problems. The ?eld of runtime veri?cation is often referred to under di?erent names, including dynamic analysis, runtime analysis, and runtime monitoring, to mention a few. Runtime veri?cation can be applied during the development of a system for the purpose of program - derstanding, debugging, and testing, or it can be applied as part of a running system, for example for security or safety policy monitoring, and can furth- more be part of a fault protection framework. A number of sub-?elds of runtime veri?cation have emerged over time, such as speci?cation languages and logics for execution analysis, dynamic analysis algorithms, program instrumentation, security monitoring, fault protection, speci? cation mining, and dynamic system visualization. Runtime veri?cationhas strong connections to other ?elds of c- puter science research, such as combinations of static and dynamic analysis, aspect-oriented programming, and model-based testing. Runtime Veri?cation events started with a workshop in 2001 and continued as an annual workshop series through 2009.