The COVID-19 virus was responsible for the deaths of over thirty-five thousand Canadians in its first two years alone. Described as the biggest public health crisis of the century, it was an uncertain threat, which emerged within complex psychological, social legal, administrative, and economic contexts. Seized by Uncertainty explains how Canadian governments responded to that threat. Despite early warning signs, the governments failed to appreciate the trade-offs required to respond to the pandemic. Their approach, at times intolerant of debate and blind to diversity, served the interests of some over others. Their response prioritized stability and containment, enabling four in ten people to work from home, disproportionately benefiting an educated middle-class, who benefited further with soaring stock markets and housing prices. Mental health issues spiked, racialized people were much more likely to test positive for the virus, those in low-income sectors experienced unstable employment and lacked workplace safety protection, the lives of low-risk youth were in constant suspension, and residents of some care homes were virtually abandoned. Seized by Uncertainty studies the pandemic response through the contexts in which it emerged, exposing how it revealed uncomfortable truths about a fragmented society and governance problems that predated the threat.