Non-Fiction Books:

Serpins and Protein Kinase Inhibitors

Novel Functions, Structural Features and Molecular Mechanisms

Format

Hardback

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Serpins and Protein Kinase Inhibitors
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Description

Serpins, a group of proteins with similar structures, were first identified as a set of proteins able to inhibit proteases. The first members of the serpin superfamily to be extensively studied were the human plasma proteins antithrombin and antitrypsin, which play key roles in controlling blood coagulation and inflammation. Today, over 1000 serpins have been identified, including 36 human proteins, as well as molecules in plants, fungi, bacteria, archaea and certain viruses. Serpins are thus the largest and most diverse family of protease inhibitors. In contrast, a protein kinase inhibitor is an enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). Protein tyrosine kinases (PTKs) play a key role in the regulation of cell proliferation, differentiation, metabolism, migration and survival. Due to their involvement in various forms of cancer, PTKs have become prominent targets for therapy. This new book gathers the latest research from around the globe in this dynamic field.
Release date Australia
March 26th, 2010
Contributors
Edited by Bojidor Georgiev Edited by Sava Markovski
Country of Publication
United States
Illustrations
tables & charts
Imprint
Nova Science Publishers Inc
Pages
257
ISBN-13
9781607411871
Product ID
3485532

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