Brian and his friends are not part of the cool crowd. They're the misfits and wily troublemakers--the ones who jump their high school's fence to skip class regularly. So when a deadly virus breaks out, they're the only ones with a chance of surviving. The virus turns Brian's classmates and teachers into bloodthirsty attackers who don't die easily. The whole school goes on lockdown, but Brian and his best friend, Chad, are safe (and stuck) in the theater department--far from Brian's sister and his ex-girlfriend with a panic attack problem. Brian and Chad, along with some of the theater kids Brian had never given the time of day before, decide to find the girls and bring them to the safety of the theater. But it won't be easy, and it will test everything they thought they knew about themselves and their classmates.