Volume Editors Tamiki Komatsuzaki is a Professor in the Molecule and LifeNonlinear Sciences Laboratory, Research Institute for ElectronicScience at Hokkaido University in Japan. His research interestsinclude origin of selectivity and stochasticity of reactions,single-molecule biophysics, as well as protein landscape andcomplexity in kinetics and dynamics. Masaru Kawakami is an Associate Professor at the JapanAdvanced Institute of Science and Technology (JAIST) School ofMaterial Science. He specializes in biophysics, single-moleculemeasurement, protein folding, and structural biology, and hisresearch focuses on single-molecule dynamics of biomolecules. Satoshi Takahashi is a Professor at the Institute ofMultidisciplinary Research for Advanced Materials, TohokuUniversity, Japan. His research focuses on protein folding andfunctional dynamics. Haw Yang is an Associate Professor in the Department ofChemistry at Princeton University. His current research focuses onhigh-resolution quantitative single-molecule protein dynamics andreal-time 3D single-particle tracking spectroscopy. Robert J. Silbey is the Class of 1942 Professor ofChemistry at MIT. His research involves theoretical studies ofsingle-molecule spectroscopy at low temperatures, energy andelectron transfer and relaxation in molecular aggregates, theoptical and electronic properties of conjugated oligomers andpolymers, and the transport of charge in organic systems. Series Editors Stuart A. Rice received his master's and doctorate from HarvardUniversity and was a junior fellow at Harvard for two years beforejoining the faculty of the University of Chicago in 1957, where heis currently the Frank P. Hixon Distinguished Service ProfessorEmeritus. Aaron R. Dinner received his bachelor's degree anddoctorate from Harvard University, after which he conductedpostdoctoral research at the University of Oxford and theUniversity of California, Berkeley. He joined the faculty at theUniversity of Chicago in 2003.