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Single-particle Cryo-EM of Biological Macromolecules on Hardback
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Single-particle Cryo-EM of Biological Macromolecules

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Description

This edited book is written for students, postdocs and established investigators who want to enter the field of single-particle cryo-EM. This is a recently developed method to determine high-resolution structures of biological macromolecules. A major strength is the fact that cryo-EM does not require prior crystallization of protein complexes. Furthermore, it is especially well suited for larger complexes and molecular machines, although it can also be used for macromolecules as small as 40 kDa or less. It also is especially well-suited to deliver high-resolution structural information about multiple conformational states. Key Features Written for students, postdocs and established investigators who want to enter the field of single-particle cryo-EM. Provides a comprehensive, accessible and authoritative introduction to the field of high-resolution structure analysis by single-article cryo-EM. Covers all necessary background, ranging from the underlying concepts to practical aspects such as specimen preparation, data-collection, data analysis, and the final validation of results.

Author Biography:

Professor Glaeser (UC Berkeley) made major contributions to the initial development of cryo-EM technology, and he currently is active in the improvement of specimen preparation. Professor Nogales (UC Berkeley) has used cryo-EM throughout her scientific career, successfully applying this technique for the last three decades to systems that defied structural characterization. Professor Chiu (Stanford University) developed early experimental and computational methods towards 3D structure determination of biomolecules toward atomic resolution.
Release date Australia
May 19th, 2021
Audience
  • Professional & Vocational
Contributors
  • Contributions by Anchi Cheng
  • Contributions by Matthew L. Baker
  • Contributions by Paul D Adams
  • Contributions by Pavel V Afonine
  • Contributions by Radostin Danev
  • Contributions by Xiao-chen Bai
  • Contributions by Yifan Cheng
  • Edited by Eva Nogales
  • Edited by Robert M Glaeser
  • Edited by Wah Chiu
Illustrations
With figures in colour and in black and white; 75 Illustrations, unspecified
Pages
318
Dimensions
178x254x19
ISBN-13
9780750330374
Product ID
34028336

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