This book is reflective of a science-based vision of the future development paradigm of economic and social systems. It deals with the digitization as the technological basis for the future development of economic and social systems and presents a review of groundbreaking technologies and prospects for their application. The specific character of the industry and prospects for the application of digital technologies in business are analyzed. A rationale is provided for future prospects for the sustainable development of economic and social systems in a digital economy. The authors determine the process of the formation and development of the information-oriented society, social and educational aspects of the digitization, as well as the institutional framework of the digital future of social and economic systems.  The book combines the best works following the results of the 12th International Research-to-Practice Conference “Artificial Intelligence: Anthropogenic Naturevs. Social Origin” that was held by the Institute of Scientific Communications (ISC) in cooperation with the Siberian Federal University and the Krasnoyarsk Regional Fund of support of scientific and scientific–technical activities on 5–7 December 2019, in Krasnoyarsk, Russia, as well as following the results of the 3rd International Research-to-Practice Conference “Economic and Social Systems: Paradigms for the Future” that was held by the ISC in cooperation with the Pyatigorsk State University on 5–6 February 2020.  The target audience of the book consists of representatives of the academic community concerned with the future prospects for the development of economic and social systems, as well as economic agents engaged in the digitization of business processes, and representatives of public agencies regulating the development of business systems for their progressivity, sustainability and competitiveness.