The Art and Science of Breakthrough Research: Unlocking Human Potential in the Age of AI is a comprehensive guide to understanding the thought processes of visionary minds like Tesla and Einstein, and how these mental models can be adapted and implemented in modern research. Drawing from extensive historical examples and case studies, the book describes tools and techniques such as associative networks, visual thinking, polymathy, and first principles reasoning as key drivers of groundbreaking ideas. It delves into the importance of individual creativity, group collaboration, perseverance, and leadership in fostering innovation. Throughout the book, practical exercises, quizzes, and mindfulness practices help readers develop their mental habits and research toolkit. This enlightening book bridges the gap between past and future research, and provides a roadmap to achieving breakthrough success in the age of AI.