The descendants of Seth and John Yates documents for the first time the families of these two men using all extant records that could be located during an exhaustive search of early New England records. Seth's children and grandchildren moved between Newport and Providence during the American Revolution and most of the descendants through to the early twentieth century were still found in New England except for his grandson Jonathan whose children moved to Michigan and Wisconsin and contained some very prominent individuals of their time. The daughters married into the Carder, Melvill, Burr, Cahoone, Cranston, Hammett, and other prominent Newport and Providence families. John's line moved first to Uxbridge, Massachusetts, and within two more generations had spread to New York State, Ohio, Illinois, Michigan, Wisconsin, and Iowa. These families were pioneers of their times, fought in the American Revolution, the Civil War, and participated in public affairs. One of John's daughters married Shem Drown and his children have been documented with never before found records. His grandsons Amariah and Barzillai were pioneers in Genesee and Tioga counties, New York, leaving numerous descendants. John's granddaughter Elizabeth married Benjamin Read and had a child who married her cousin, identified here for the first time.