Gregory L. Verdine, Department of Stem Cell and Regenerative Biology, Chemistry and Chemical Biology and Molecular and Cellualr Biology, Harvard University Susan K. Dutcher, Department of Genetics, Washington University School of Medicine Tom A. Rapoport, Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School Michael E. Greenberg, Children's Hospital Boston, Program in Neurobiology and Harvard Medical School, Department of Neurobiology Kathryn V. Anderon, Developmental Biology Program, Sloan-Kettering Institute Leonard I. Zon, Grousbeck Professor of Pediatrics, Children's Hospital Boston, Howard Hughes Medical Institute Michael Karin, Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, Cancer Center, School of Medicine, University of California at San Diego