Gamblers have been trying to figure out how to game the system since our ancestors first made wagers over dice fashioned from knucklebones: in revolutionary Paris, the 'martingale' strategy was rumoured to lead to foolproof success at roulette; today, professional gamblers are using cutting-edge techniques to tilt the odds in their favour. Science is giving us the competitive edge over opponents, casinos and bookmakers. But is there such a thing as a perfect bet? The Perfect Bet looks beyond probability and statistics to examine how wagers have inspired a plethora of new disciplines - spanning chaos theory, machine learning and game theory - which are not just revolutionising gambling, but changing our fundamental notions about chance, randomness and luck. Explaining why poker is gaming's last bastion of human superiority over AI, how methods originally developed for the US nuclear programme are helping pundits predict sports results and why a new breed of algorithms are losing banks millions, The Perfect Bet has the inside track on any wager you'd care to place.