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Thymic Development and Selection of T Lymphocytes

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Description

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
Release date Australia
August 23rd, 2016
Audience
  • Professional & Vocational
Contributors
  • Edited by Thomas Boehm
  • Edited by Yousuke Takahama
Edition
Softcover reprint of the original 1st ed. 2014
Illustrations
9 Illustrations, color; 2 Illustrations, black and white; VII, 132 p. 11 illus., 9 illus. in color.
Pages
132
Dimensions
155x235x8
ISBN-13
9783662511961
Product ID
25684361

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