Professor Peter Vaupel studied Medicine at the University of Mainz and was awarded the degree of M.D. in 1968 and the degree of Dr. med. in 1969. Thereafter, he underwent training in surgery, internal medicine, obstetrics and gynaecology, and following military service he returned to academic life at the Institute of Physiology, University of Mainz, as a research assistant. His interests turned to the microenvironment of solid tumors. This new area of research proved to be so fascinating and compulsive for Dr. Vaupel that it has kept him occupied for over 30 years! Initially, Dr. Vaupel carried out theoretical and experimental studies on oxygenation and metabolites in tissue-isolated tumors, for which he was awarded the degree of Dr. med. habil. In 1974. Following promotions to Assistant Professor (1972) and Associate Professor (1975), Dr. Vaupel was appointed Full Professor of Physiology in 1977 and became Head of the Department of Applied Physiology at the University of Mainz in 1984. In 1987 he left Mainz to take up the newly established Andrew Werk Cook Professorship of Radiation Biology/Physiology at Harvard Medical School. In 1989 Dr. Vaupel assumed the position as Professor and Chairman of the Department of Pathophysiology at the Institute of Physiology and Pathophysiology at the Johannes Gutenberg-University of Mainz. Since 1998, Professor Vaupel has been a Full Member of the Academy of Science and Literature at Mainz. Dr. Vaupel has managed to dedicate a great deal at effort to the teaching of physiology, as documented by five standard textbooks of Physiology and Pathophysiology. He serves in an advisory capacity to many national and international science foundations and is currently a member of several professional societies, serves on the editorial boards of numerous professional journals and has edited a series of monographs addressing topics in tumor pathophysiology. Over the past 33 years, Dr. Vaupel has published more than 360 well-cited articles and made approximately 560 scientific presentations in which a wide range of therapeutically relevant pathophysiological parameters have been examined. Over the last 25 years, a major focus of Dr. Vaupel’s research has been on the effects of hyperthermia, and much of this research has concentrated on the reciprocal influence of microenvironmental parameters and hyperthermia. With these studies he has made a considerable contribution to our current knowledge of the pathophysiological behaviour of solid tumors upon localized heat treatment and the impact of the special tumor pathophysiology on treatment outcome. In cooperation with Dr. Debra Kelleher, ongoing research is focusing on the development of new treatment modalities such as simultaneously applied combination of localized hyperthermia and photodynamic therapy.